Horses have a biological signaling system within their bodies called the endocannabinoid system (ECS). This system is not unique to horses and is shared by mammals and some other animals. It functions as a regulator of homeostasis within the body and is comprised of three main components. These components are 1) endocannabinoids, 2) cannabinoid receptors, and 3) activating and deactivating enzymes. Understanding this signaling system can provide insights to the possible ways in which CBD can work to produce potentially therapeutic effects in horses as well as other animals.
Activating and deactivating enzymes
The three components described above work together to convert biochemical signals into physiological responses that contribute to the maintenance of homeostasis throughout the body. Knowledge about this system and its components provides valuable insight to the potential effects that CBD can have when introduced to this system.
- Bruni, N.; Della Pepa, C.; Oliaro-Bosso, S.; Pessione, E.; Gastaldi, D.; Dosio, F. Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules 2018, 23, 2478. • Silver, R.J. The Endocannabinoid System of Animals. Animals 2019, 9. • Zou, S.; Kumar, U. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. Int. J. Mol. Sci. 2018, 19.